Vitiligo consists of white patches of skin that are caused by the loss of melanin, the pigment that gives skin its color. Melanin is produced by special cells called melanocytes, which are destroyed in people who have vitiligo. Experts are still working out the details to understand why this disease occurs, but evidence strongly suggests that vitiligo is an autoimmune disorder, in which the body's immune system mistakenly targets and injures these specific cells within your own body.
Vitiligo can cause minor changes or extensive changes in the skin. In some people, it may be hardly noticeable, while in others it is obvious. In dark-skinned people the vitiligo patches are obvious since they contrast with normal skin. Light-skinned people may have fewer cosmetic concerns, but patches without pigment can become obvious in the summer because unaffected skin tans but vitiligo skin does not tan.
Vitiligo occurs in about 1% to 2% of the population. Approximately 30% of people with vitiligo have a family history of the condition. About half of people with vitiligo start showing symptoms before age 20.
People with vitiligo have an increased risk of developing certain diseases, such as hypothyroidism (an underactive thyroid), hyperthyroidism (an overactive thyroid), type 1 diabetes , Addison's disease (a disease that causes a decrease in the function of the adrenal gland) and pernicious anemia (vitamin B12 deficiency). Also, people with these conditions have an increased risk of developing vitiligo. These medical conditions are all problems that involve the immune system attacking cells in the body.
Vitiligo causes patches of white skin that are often symmetrical (even), with dark or red borders. The patches can occur anywhere, but the areas most commonly affected are the backs of the hands, the face, and areas that have skin folds, such as the armpits and genitals. Body openings, such as the lips, eyes, nipples and anus are also common areas for vitiligo, as are areas that have been sunburned.
Vitiligo can occur in bursts, so that sizeable areas of skin may rapidly lose their pigment during the beginning stages of the condition, yet then these whitened skin patches may abruptly stop expanding for months or years.
Vitiligo causes a pattern of skin changes that usually can be recognized easily by a doctor. If the skin changes are in a pattern that suggests other conditions, your doctor might recommend a biopsy of the skin to be certain about your diagnosis. In a biopsy, a small piece of skin is removed and examined in a laboratory. A biopsy usually is not needed to diagnose vitiligo.
In 1 out of every 5 to 10 people, some or all of the pigment eventually returns on its own and the white patches disappear. For most people, however, the whitened skin patches last and grow larger if vitiligo is not treated. Vitiligo is a lifelong condition.
There is no way to prevent vitiligo.
Vitiligo can be treated if it causes emotional or social distress. The goals of treatment are to minimize the contrast in color between your normal skin and skin patches that have lost pigment. If you are light-skinned, part of your treatment may be to protect your normal skin from tanning by using sunscreens with a sun protection factor (SPF) of at least 15.
You can try to get normal skin color to return in the areas affected by vitiligo with treatment called repigmentation therapy, which can take several forms:
If you notice that patches of skin appear white, contact your doctor for an examination. Treatment may be most helpful if it can be started when only a small area of skin is affected. It is very important to wear sunscreen to protect the areas affected by vitiligo, since these areas are especially at risk for sunburn and for skin cancers.
For most people with vitiligo, this condition slowly worsens without treatment or needs continued treatment.
American Academy of Dermatology
P.O. Box 4014
Schaumburg, IL 60168-4014