Chrome 2001
.
Aetna Intelihealth InteliHealth Aetna Intelihealth Aetna Intelihealth
 
.
. .
.
Chrome 2001
Chrome 2001
Health News Health News
.
Speedy Delivery of Clot-Busting Drug Helps Stroke Patients Avoid Disability
August 06, 2014

 

WEDNESDAY, Aug. 6, 2014 (HealthDay News) Another study confirms that "time is brain" when treating stroke patients with a powerful clot-busting drug, tPA.

Prompt treatment with tissue plasminogen activator (tPA, also known as alteplase) "is a very effective means of limiting the degree of disability in stroke patients," study co-author Dr. Jonathan Emberson, of University of Oxford in the U.K., said in a news release from the journal The Lancet.

The study, published in the journal on Aug. 5, also reinforces the idea that the quicker that patients can get tPA, the better.

One U.S. expert agreed. "The analysis reiterates the importance of patients going to the ER immediately at the time of developing acute neurological symptoms that could be due to a stroke," said Dr. Rafael Alexander Ortiz, director of interventional neuroradiology and stroke at Lenox Hill Hospital in New York City.

Clot-busting drugs are used to treat people who have suffered an ischemic stroke, which occurs when a clot blocks blood flow to the brain.

In the study, Emberson's team looked at data from more than 6,700 stroke patients who took part in nine clinical trials involving tPA.

The likelihood of a good outcome -- defined as no significant disability three to six months after stroke -- were 75 percent higher for patients who received the drug within three hours of initial stroke symptoms, compared with patients didn't get tPA.

While that three-hour window is ideal, even patients who got tPA a bit later received some benefit. For example, the chances of a good outcome were still 26 percent higher among patients who received the clot-buster within 4.5 hours of the attack, and 15 percent higher for those who received the drug more than four to five hours after initial stroke symptoms, the group found

The benefits of quick treatment with tPA were seen in all patient groups, including those older than 80 and those with severe strokes, the authors add.

There was a slight added risk with the drug, however: the researchers also found that tPA increased the risk of dying from brain bleeding by about 2 percent within the first few days after stroke.

One U.S. stroke expert called the new review "powerful."

"The information is very significant because it helps support our concept of 'time is brain' by showing that faster treatment times do result in better outcomes for patients," said Dr. Keith Siller, director of the Stroke Consultative Services at North Shore-LIJ's Cushing Neuroscience Institute in Manhasset, N.Y.

He said that the finding that tPA helped even elderly patients was key, because "there has been a negative bias about offering IV tPA because of concerns about decreased clinical benefit and increased hemorrhage in this subset of patients."

In the Lancet news release, study co-author Kennedy Lees, a professor of cerebrovascular medicine at the University of Glasgow, in Scotland, said that "what this shows is that we are up against the clock when treating ischemic stroke. Every minute counts. People need to be identified quickly and systems need to be in place to get them scanned, diagnosed accurately and then treated within minutes to hours."

More information

The American Heart Association/American Stroke Association has more about stroke treatments.


SOURCES: Rafael Alexander Ortiz, M.D. director, Neuro-Endovascular Surgery/Interventional Neuroradiology and Stroke, Lenox Hill Hospital, New York City; Keith A. Siller, M.D. director, Stroke Consultative Services, North Shore-LIJ's Cushing Neuroscience I...

InteliHealth
.
.
.
.
.
More News
InteliHealth .
.
General Health News
Today's News
Today In Health History
This Week In Health
Addiction News
Allergy News
Alzheimer's News
Arthritis News
Asthma News
Babies News
Breast Cancer News
Bronchitis News
Cancer News
Cervical Cancer News
Children's Health News
Cholesterol News
Dental/Oral Health News
Depression News
Diabetes News
Ear, Nose And Throat News
Environmental Health News
Eye News
Fitness News
Genetics News
Headache News
Health Policy News
Heart Attack News
Heart Failure News
Heart Health News
HIV/AIDS News
Infectious Diseases News
Influenza News
Lung Cancer News
Medication News
Men's Health News
Mental Health News
Multiple Sclerosis News
Nutrition News
Parkinson's News
Pregnancy News
Prostate Cancer News
Schizophrenia
Senior Health News
Sexual/Reproductive Health News
Sexual dysfunction
Sleep News
STDs News
Stroke News
Tobacco Cessation News
Weight Management News
Women's Health News
.
.
.
.
InteliHealth
    Print Printer-friendly format    
   
.  
This website is certified by Health On the Net Foundation. Click to verify.
.