Chrome 2001
.
Aetna Intelihealth InteliHealth Aetna Intelihealth Aetna Intelihealth
 
.
. .

   Advertisement
Carepass Ad Carepass Ad .
Chrome 2001
Chrome 2001
InteliHealth
Ask the Doc
4464
Ask the Doc
Ask The Expert
Harvard Medical School
Image of a cadeusus
. .
General Medical Questions
.
Question : I was diagnosed with Idiopathic Pulmonary Fibrosis 2 1/2 yrs ago and am currently on oxygen. I feel fine except when I do too much walking or cleaning without the oxygen. Are there any new or experimental treatments out there?
.
.
.
The Trusted Source
.
.
Howard LeWine, M.D.

Howard LeWine, M.D., is chief editor of Internet Publishing, Harvard Health Publications. He is a clinical instructor of medicine at Harvard Medical School and Brigham and Women's Hospital. Dr. LeWine has been a primary care internist and teacher of internal medicine since 1978.

.
.
January 20, 2011
.

A:

Idiopathic pulmonary fibrosis is a poorly understood disease. In fact, any disease that is called "idiopathic" usually means that the cause is not known.

Early on in the disease, there is inflammation in the lungs. But the main problem in pulmonary fibrosis is that scar tissue replaces the normal breathing sacs (alveoli) in the lungs.

Inflammation may not be the reason scar tissue forms. (The inflammation might be an innocent bystander.) In fact, many strong anti-inflammatory drugs have been tried with minimal success.

Even so, lung specialists often recommend a trial of corticosteroids such as prednisone or methylprednisolone. This may be combined with another anti-inflammatory drug such as azathioprine.

Researchers are studying drugs that may be able to stop the fibrosis (the formation of scar tissue). One drug is pirfenidone. The Food and Drug Administration is reviewing this drug. It is approved for treating pulmonary fibrosis in other countries.

Another drug that shows some promise is bosentan (Tracleer). Animal studies show that bosentan can decrease scarring. The results of human studies so far are somewhat encouraging. Additional studies are under way.

.

4581, 8760,
drug,inflammation,pulmonary fibrosis,anti-inflammatory
4581
dmtATD

.
.
InteliHealth
.
Ask A Question
.
.
InteliHealth
Do You Have A Question?
.
. . .
.
Ask The Expert Archives
Topics
.
InteliHealth
.
InteliHealth

    Print Printer-friendly format    
   
dmtatd
dmtATD
dmtatd
126747
InteliHealth
1998-05-15
f
InteliHealth
NULL
411, 4464, 4581, 4582, 7991, 7992, 7995, 7996, 7997, 8122, 8438, 8463, 8464, 8465, 8466, 8467, 8468, 8469, 8470, 8471, 8472, 8473, 8474, 8475, 8476, 8477, 8479, 8480, 8481, 8482, 8483, 8484, 8486, 8487, 8488, 8489, 8490, 8760, 14219, 20807, 21346, 21349, 21351, 23926, 23938, 24017, 24025, 24075, 24151, 24510, 24519, 24549, 24869, 24878, 25107, 25518, 25646, 25968, 29367, 29516, 29595, 48666, 48812, 59367,
4581
.
.  
This website is certified by Health On the Net Foundation. Click to verify.
.