Some people with diabetes can’t comfortably tolerate a glucose level that is at the lower end of the ideal target range. Their bodies react to near-normal blood sugars with an early release of the hormone norepinephrine. And they can have symptoms that are similar to symptoms of hypoglycemia.In some cases, the actual level of blood sugar that causes alarm symptoms in a person with diabetes can be as many as 20 points higher than the level of low sugar that would cause symptoms in a  person without diabetes. Scientists refer to this situation as an “altered glycemic threshold.” It is more likely to happen when diabetes has been in poor control. Poor control means that blood sugar levels are running much higher than optimal.Doctors have a theory to explain this problem: brain cells and other cells persistently exposed to high glucose levels adjust to their environment. In response to being bathed in a high sugar solution, these cells make fewer sugar receptors on the cell surface. With fewer sugar receptors on their surfaces, cells don’t capture as much glucose floating in the blood stream. And this means less glucose moves into cells.The good news is that this process can be reversed. But it takes time. People who have symptoms when sugars are still in the goal range have been shown to lose these symptoms after their glucose levels have been gradually lowered and their average glucose reaches desirable levels. Doctors measure average blood sugar levels with a test called hemoglobin A1C.If you have symptoms at “normal” glucose levels, then these lower levels are not ideal for you. Talk with your doctor about a goal customized for your glucose control target range and your hemoglobin A1C level. Your target range should not cause you to have hypoglycemic symptoms.