Another Study Strikes at the Heart of Niacin Benefits: There Are None

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Another Study Strikes at the Heart of Niacin Benefits: There Are None

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Another Study Strikes at the Heart of Niacin Benefits: There Are None
March 12, 2013

(USA TODAY) -- Niacin, a B vitamin that has been a mainstay of heart treatment for years, provided no benefit in a major new study and may even cause harm.

Niacin is commonly used to try to lower "bad" LDL cholesterol and raise "good" HDL cholesterol.

In a study of 25,000 people taking cholesterol-lowering statin drugs, doctors randomly assigned people to get either a placebo or niacin plus another drug to reduce flushing, a common side effect of niacin.

The niacin combination had no benefit, with no reduction in the rate of heart problems such as heart attacks, stroke or death.

But patients given niacin had a higher risk of bleeding, infections, new-onset type 2 diabetes or diabetic complications, according to a study presented Saturday at a meeting of the American College of Cardiology in San Francisco.

Although doctors hoped niacin would prevent heart attacks and strokes, "we now know that its adverse side effects outweigh the benefits," says lead author Jane Armitage, a professor at England's University of Oxford, in a statement.

The study is the latest in a string of bad news for niacin.

A 2011 study found that it failed to reduce heart attacks, even though it boosted good cholesterol. Alarmingly, researchers found that users of niacin had a slightly higher risk of stroke, although this could have been a coincidence.

Niacin's poor performance in rigorously controlled trials is a disappointment, given that Americans spent $800 million a year on brand-name, extended-release niacin, says Robert Giugliano of Harvard Medical School in an editorial accompanying the 2011 study in The New England Journal of Medicine.

To A. Marc Gillinov, a heart surgeon at the Cleveland Clinic, the study is "another nail in the coffin for niacin."

Copyright 2013 USA TODAY, a division of Gannett Co. Inc.

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Last updated March 12, 2013


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