The pain and stiffness typical of osteoarthritis are usually gradual in onset. Symptoms can range from mild to severe, usually worsen with use or movement, and are relieved by rest. In its most severe form, pain may be present even at rest, including at night. The degenerative process may begin in one or more joints, usually the knees, hips, hands, feet or spine (neck and/or lower back).

As with any chronic pain, individual experience is extremely variable. People who have osteoarthritis often complain of a deep ache centered in the joint. However, some people with osteoarthritis describe the pain as throbbing, gnawing or sharp. Rest usually relieves osteoarthritic pain, although the pain becomes more constant as the disease progresses. Significant pain during the night can interfere with sleep. Sleep disruption of this kind suggests severe (end-stage) osteoarthritis.

Typical symptoms of osteoarthritis include: