Adenocarcinoma of the lung is a type of lung cancer. It occurs when abnormal lung cells multiply out of control and form a tumor. Eventually, tumor cells can spread (metastasize) to other parts of the body including the:

• Lymph nodes around and between the lungs
• Liver
• Bones
• Adrenal glands
• Brain

Compared with other types of lung cancer, adenocarcinoma is more likely to be contained in one area. If it is truly localized, it may respond to treatment better than other lung cancers.

Adenocarcinoma is the most common form of lung cancer. It's generally found in smokers. However, it is the most common type of lung cancer in nonsmokers. It is also the most common form of lung cancer in women and people younger than 45.

As with other forms of lung cancer, your risk of adenocarcinoma increases if you:

• Smoke. Smoking cigarettes is by far the leading risk factor for lung cancer. In fact, cigarette smokers are 13 times more likely to develop lung cancer than nonsmokers. Cigar and pipe smoking are almost as likely to cause lung cancer as cigarette smoking.



• Breathe tobacco smoke. Nonsmokers who inhale fumes from cigarette, cigar, and pipe smoking have an increased risk of lung cancer.



• Are exposed to radon gas. Radon is a colorless, odorless radioactive gas formed in the ground. It seeps into the lower floors of homes and other buildings and can contaminate drinking water. Radon exposure is the second leading cause of lung cancer. It's not clear whether elevated radon levels contribute to lung cancer in nonsmokers. But radon exposure does contribute to increased rates of lung cancer in smokers and in people who regularly breathe high amounts of the gas (miners, for example). You can test radon levels in your home with a radon testing kit.



• Are exposed to asbestos. Asbestos is a mineral used in insulation, fireproofing materials, floor and ceiling tiles, automobile brake linings, and other products. People exposed to asbestos on the job (miners, construction workers, shipyard workers, and some auto mechanics) have a higher-than-normal risk of lung cancer. People who live or work in buildings with asbestos-containing materials that are deteriorating also have an increased risk of lung cancer. In addition to having a higher risk of adenocarcinoma, people who have been exposed to asbestos have a greater risk of developing mesothelioma. This is a type of cancer that starts in the tissue surrounding the lungs.



• Are exposed to other cancer-causing agents at work. These include uranium, arsenic, vinyl chloride, nickel chromates, coal products, mustard gas, chloromethyl ethers, gasoline, and diesel exhaust.

All lung cancers, including adenocarcinoma, have similar symptoms. They include:

• A cough that doesn't go away
• Coughing up blood or mucus
• Wheezing
• Shortness of breath
• Trouble breathing
• Chest pain
• Fever
• Discomfort when swallowing
• Hoarseness
• Weight loss
• Poor appetite

If the cancer has spread beyond the lungs, it can cause other symptoms. For example, you may have bone pain if it has spread to your bones.

Many of these symptoms can be caused by other conditions. See your doctor if you have symptoms so that the problem can be diagnosed and properly treated.

Your doctor will start by taking your health history. He or she will ask about your smoking habits and whether you live with a smoker. Your doctor also will ask whether you may have been exposed to asbestos or other cancer-causing agents at work.

Next, he or she will order imaging tests to check your lungs for masses. In most cases, a chest X-ray will be done first. If the X-ray shows anything suspicious, a computed tomography (CT) scan will be done. As the scanner moves around you, it takes many pictures. A computer then combines the images. This creates a more detailed image of the lungs, allowing doctors to confirm the size and location of a mass or tumor.

You may also have a magnetic resonance imaging (MRI) scan or a positron emission tomography (PET) scan. MRI scans provide detailed pictures of the body's organs, but they use radio waves and magnets to create the images, not X-rays. PET scans look at the function of tissue rather than anatomy. Lung cancer tends to show intense metabolic activity on a PET scan. Some medical centers offer combined PET-CT scanning.

If cancer is suspected based on these images, more tests will be done to make the diagnosis, determine the type of cancer, and see if it has spread. These tests may include the following:

• Sputum sample. Coughed-up mucus is checked for cancer cells.



• Biopsy. A sample of abnormal lung tissue is removed and examined under a microscope in a laboratory. The tissue is often obtained during a bronchoscopy. However, surgery may be necessary to expose the suspicious area.



• Bronchoscopy. During this procedure, a tube-like instrument is passed down the throat and into the lungs. A camera on the end of the tube allows doctors to look for cancer and to remove a small piece of tissue for a biopsy.



• Mediastinoscopy. In this procedure, a tube-like instrument is used to biopsy lymph nodes or masses between the lungs. (This area is called the mediastinum.) A biopsy obtained this way can diagnose the type of lung cancer and determine whether the cancer has spread to lymph nodes.



• Fine-needle aspiration. With a CT scan, a suspicious area can be identified. A tiny needle is then inserted into that part of the lung. The needle removes a bit of tissue for examination in a laboratory. The type of cancer can then be diagnosed.



• Thoracentesis. If there is fluid build-up in the chest, it can be drained with a sterile needle. The fluid is then checked for cancer cells.



• VATS (video-assisted thoracoscopy). In this procedure, a surgeon inserts a flexible tube with a video camera on the end into the chest through an incision. He or she can then look for cancer in the space between the lungs and the chest wall. Abnormal lung tissue can also be removed.



• CT, PET, and bone scans. These imaging tests can detect lung cancer that has spread to the brain, bones, or other parts of the body.

After the cancer has been diagnosed, it is assigned a "stage." The stage indicates the tumor's size and how far it has spread. Stages I through III are further divided into "A" and "B" categories. Stage I tumors are small and have not invaded surrounding tissues. Stage II and III tumors have invaded surrounding tissues and/or organs and have spread to lymph nodes. Stage IV tumors have spread beyond the chest.

Adenocarcinoma of the lung will continue to grow and spread until it is treated.

To reduce your risk of adenocarcinoma and other forms of lung cancer:

• Don't smoke. If you already smoke, talk to your doctor about getting the help you need to quit.



• Avoid secondhand smoke. Choose smoke-free restaurants and hotels. Ask guests to smoke outdoors, especially if there are children in your home.



• Reduce exposure to radon. Have your home checked for radon gas. A radon level above 4 picocuries/liter is unsafe. If you have a private well, have your drinking water checked, too. Kits to test for radon are widely available.



• Reduce exposure to asbestos. Because there is no safe level of asbestos exposure, any exposure is too much. If you have an older home, check to see if any insulation or other asbestos-containing material is exposed or deteriorating. The asbestos in these areas must be professionally removed or sealed up. If the removal isn't done properly, you may be exposed to more asbestos than you would have been if it has been left alone. People who work with asbestos-containing materials should use approved measures to limit their exposure and to prevent bringing asbestos dust home on their clothing.

Treatment depends on the cancer's stage as well as the patient's condition, lung function, and other factors. (Some patients may have other lung conditions, such as emphysema or COPD -- chronic obstructive pulmonary disease.) If the cancer has not spread, surgery is usually the treatment of choice. There are three types of surgery:

• Wedge resection removes only a small part of the lung.
• Lobectomy removes one lobe of the lung.
• Pneumonectomy removes an entire lung.

Lymph nodes are also removed and examined to see if the cancer has spread.

Some surgeons use video-assisted thoracoscopy (VATS) to remove small, early-stage tumors, especially if the tumors are near the outer edge of the lung. (VATS can also be used to diagnose lung cancer.) Because the incisions for VATS are small, this technique is less invasive than a traditional "open" procedure.

Because surgery will remove part or all of a lung, breathing may be more difficult afterwards, especially in patients with other lung conditions (emphysema, for example). Doctors can test lung function prior to surgery and predict how it might be affected by surgery.

Depending on how far the cancer has spread, treatment may include chemotherapy (the use of anticancer drugs) and radiation therapy. These may be given before and/or after surgery.

When the tumor has spread significantly, chemotherapy may be recommended to slow its growth, even if it cannot cure the disease. Chemotherapy has been shown to ease symptoms and prolong life in cases of advanced lung cancer.

Radiation therapy can relieve symptoms, too. It is often used to treat lung cancer that has spread to the brain or bones and is causing pain. It can also be used alone or with chemotherapy to treat the lung cancer that is confined to the chest.

People who may not withstand surgery due to other serious medical problems may receive radiation therapy, with or without chemotherapy, to shrink the tumor.

In specialized cancer centers, cancerous tissue may be tested for specific genetic abnormalities (mutations). Doctors may then be able to treat the cancer with a "targeted therapy." These therapies can derail the cancer's growth by preventing or changing chemical reactions linked to particular mutations. For example, some target therapies prevent cancer cells from receiving chemical "messages" telling them to grow.

Knowing about specific genetic mutations can help predict which therapy will be best. This strategy can be especially helpful in certain patients, such as women with adenocarcinoma of the lung who have never smoked.Even after treatment has been completed, lung cancer patients must return for regular follow-up appointments. Even if the cancer was initially "cured," it can return months or even years later.

Call your doctor promptly if you have any symptoms of lung cancer, especially if you smoke or have been exposed to asbestos.

The outlook depends on the cancer's stage and the patient's overall health. In general, the prognosis is poor, especially if the lung cancer has spread beyond the chest or has invaded lymph nodes between the lungs.

Adenocarcinoma of the lung can only be cured if the entire tumor is removed surgically or destroyed with radiation. However, many lung cancers are diagnosed at a stage when this is not possible. Less than one-fifth of patients survive five years or longer.

National Cancer Institute (NCI)
U.S. National Institutes of Health
Public Inquiries Office
Building 31, Room 10A03
31 Center Drive, MSC 8322
Bethesda, MD 20892-2580
Phone: 301-435-3848
Toll-Free: 1-800-422-6237
TTY: 1-800-332-8615
http://www.nci.nih.gov/

American Cancer Society (ACS)
1599 Clifton Road, NE
Atlanta, GA 30329-4251
Toll-Free: 1-800-227-2345
http://www.cancer.org/

American Lung Association
61 Broadway, 6th Floor
New York, NY 10006br />Phone: 212-315-8700
Toll-Free: 1-800-548-8252http://www.lungusa.org/

National Heart, Lung, and Blood Institute (NHLBI)
P.O. Box 30105
Bethesda, MD 20824-0105
Phone: 301-592-8573
TTY: 240-629-3255
Fax: 301-592-8563
http://www.nhlbi.nih.gov/

U.S. Environmental Protection Agency (EPA)
Ariel Rios Building
1200 Pennsylvania Ave., N.W.
Washington, DC 20460
Phone: 202-272-0167
http://www.epa.gov/