A brain tumor is a mass of abnormally growing cells in the brain or skull. It can be benign (noncancerous) or malignant (cancerous). Unlike other cancers, a cancer arising from brain tissue (a primary brain cancer) rarely spreads. Whether benign or malignant, all brain tumors are serious. A growing tumor eventually will compress and damage other structures in the brain.

There are two categories of brain tumors: primary and secondary. Primary tumors start in brain tissue, while secondary tumors spread to the brain from another area of the body. Primary tumors are classified by the tissue in which they begin:

• Gliomas, the most common primary tumors, start in the brain's glial (supportive) tissue. There are several types of gliomas, and they can vary in their aggressiveness and response to treatment. Glioblastoma multiforme is a fast-growing, higher-grade tumor that can arise from a lower-grade glioma.

• Medulloblastomas come from early embryonic cells and more commonly occur in children.

• Meningiomas are related to cells in the membranes surrounding the brain and spinal cord. They are usually benign, but can come back (recur) after treatment.

Secondary tumors most commonly arise from the lungs or breast. Other cancers, especially melanoma (a type of skin cancer), renal cell cancer (a type of kidney cancer), and lymphoma (a cancer of the immune system) can spread to the brain. When this happens, the cancer is the same as the original cancer. For example, lung cancer that spreads to the brain is known as metastatic lung cancer, because the tumor's cells resemble abnormal lung cells. Secondary brain tumors are much more common than primary tumors.

Although brain tumors can occur at any age, they most commonly affect adults 40 to 70 years old and children 3 to 12 years of age. Whether the use of cellular phones contributes to the development of brain tumors, especially in children, has sparked debate. The issue is far from resolved, and additional research is needed.

The symptoms of a brain tumor often are the same as those of other diseases and may develop gradually. That's why they may be overlooked for a long time before diagnosis.

Although a brain tumor rarely causes headaches, someone with no history of headaches who develops them should be seen by a doctor. Headaches from a brain tumor tend to be worse upon waking and ease during the day. Other symptoms may include:

• Vomiting and nausea

• New onset of seizures

• Weakness involving one side of the body, such as an arm and leg on the same side

• Trouble talking or change in speech

• Loss of coordination

• Changes in vision or abnormal eye movements

• Memory or personality changes

• Ringing and hearing loss in one ear

The symptoms noted above are not specific for brain tumor. In fact, most often any of these symptoms are related to some other cause.

The specific symptoms of a brain tumor depend on its size and location. They can be caused by several factors, including:

• Increased pressure in the skull

• Damage to vital tissue

• Swelling and fluid buildup

• Hydrocephalus, sometimes called "water on the brain," which results when the flow of cerebrospinal fluid is blocked and builds up in the brain

Diagnosis often begins with a medical history. Your doctor will ask about your symptoms, health habits, and past illnesses and treatments. He or she will also do a neurological exam to check your:

• Reflexes

• Coordination

• Alertness

• Response to pain

• Muscle strength

• Eyesight

Your doctor may also order one of these imaging tests:

• Computed tomography (CT) scan. This test creates cross-sectional images of the brain. It uses an x-ray camera that rotates around the body. A dye sometimes is injected into a vein prior to the scan to make the tumor more visible.

• Magnetic resonance imaging (MRI). . This test uses a powerful magnet, radio waves, and a computer to create pictures of the brain. An MRI may provide a better view of some parts of the brain than a CT scan. A special dye may be injected into the bloodstream to enhance the images. A magnetic resonance angiogram is similar to an MRI, but it looks at the flow of blood in arteries. This can help doctors find aneurysms or better define tumors.

• Positron emission tomography (PET) scan. For this test, radioactive glucose (sugar) is injected into a vein. A rotating scanner highlights areas where cells are consuming lots of glucose. (Cancer cells use more glucose than normal cells.)

If a brain tumor is suspected to be a secondary cancer, imaging tests also may be done of other organs.

Your doctor may also want to do a lumbar puncture (spinal tap). During this test, spinal fluid is taken from the lower back with a needle. The fluid can be checked for signs of infection or cancer cells.

In rare cases, doctors may want to remove a small piece of tumor tissue before diagnosing the cancer. This is called a biopsy.

Meningiomas can remain the same size for many years without causing problems. Other types of brain tumors will continue growing until they are treated. Without treatment, permanent brain damage or death can result. Many brain tumors can lead to death even with the best treatment.

There is no known way to prevent primary brain tumors. As more is learned about what causes them, more may be done to prevent them. Researchers are studying genetic and hereditary factors, exposure to certain chemicals, and exposure to certain viruses.

Some secondary brain tumors that originally started in other organs can be prevented. For example, avoiding tobacco products decreases the risk of lung cancer, thereby decreasing the chance that lung cancer cells ever appear in the brain.

Treatment depends on the tumor's size, location, and type, as well as the patient's age and general health. The main treatments include surgery, radiation therapy, and chemotherapy. A combination of treatments -- surgery and radiation therapy, for example -- is often used. Before treatment, a patient may be given corticosteroid drugs to reduce swelling of brain tissue. Anticonvulsant drugs also may be prescribed to prevent or control tumor-related seizures.

When possible, surgery is the treatment of choice for primary brain tumors. Surgery can successfully remove some benign and malignant brain tumors. Even if the entire tumor cannot be removed, surgeons will likely take out as much as possible to help relieve symptoms.

In some cases, a tumor cannot be removed surgically or surgery is too risky. For example, the tumor may abut or wrap around critical normal tissues. Damage to these tissues during surgery could cause the patient significant disability.

Stereotactic surgery, which uses computers and imaging devices to create three-dimensional pictures of the brain, can be used to remove tumors or to place radioactive materials in the tumor. Stereotactic surgery is especially helpful in reaching tumors deep in the brain. It can help pinpoint the tumor's edges, too, meaning that surgeons remove less normal tissue. This lowers the chances of side effects and brain injury.

Radiation therapy, which uses high-powered X-rays to kill cancer cells, often follows surgery. It helps destroy any pieces of the tumor that could not be surgically removed and any remaining cancer cells. Because high-dose radiation can damage normal tissue, doctors try to precisely target the tumor, limiting the amount of radiation to surrounding parts of the brain. Radiation also can be given by putting radioactive material into the tumor itself.

Radiation alone can cure some brain cancers. For example, radiation can cure up to half of all medulloblastomas. It seems to be most effective against rapidly growing cells, meaning that high-grade (fast-growing) tumors more responsive to radiation therapy than low-grade (slow-growing) tumors. Radiation also is used when surgery is not an option.

Two relatively new methods of delivering radiation -- Gamma Knife and CyberKnife -- are proving effective against brain tumors. They allow doctors to more precisely aim the radiation beam at the tumor and better spare surrounding normal tissue. However, these therapies are offered only at specialized medical centers.

Chemotherapy uses drugs to stop the growth of cancer cells. It can be taken by mouth, injected into a vein or muscle, or placed directly into a body part. In general, chemotherapy is less effective against brain tumors than surgery or radiation. However, it may be given for primary or secondary brain cancers that do not respond well to other treatments.

See your doctor right away if you have:

• New seizures

• New and severe headaches

• Sudden changes in vision

• Speech difficulties

Call your doctor if you have unexplained weakness or memory or personality changes.

Early detection and treatment offer the best chance of recovery from both benign and malignant brain tumors. The outlook also depends on:

• The type of tumor

• The tumor's size and location

• The patient's age

• The extent of any surgery

• How the tumor affects the patient's ability to function

In general, lower-grade tumors have a better prognosis.

American Cancer Society (ACS)
1599 Clifton Road, NE
Atlanta, GA 30329-4251
Toll-Free: 1-800-227-2345
http://www.cancer.org/

American Brain Tumor Association
2720 River Road
Des Plaines, IL 60018
Phone: 847-827-9910
Toll-Free: 1-800-886-2282
Fax: 847-827-9918
http://hope.abta.org

National Cancer Institute (NCI)
U.S. National Institutes of Health
Public Inquiries Office
Building 31, Room 10A03
31 Center Drive, MSC 8322
Bethesda, MD 20892-2580
Phone: 301-435-3848
Toll-Free: 1-800-422-6237
TTY: 1-800-332-8615
http://www.nci.nih.gov/

National Brain Tumor Society
East Coast Office
124 Watertown Street, Suite 2D
Watertown, MA 02472
Phone: 617-924-9997
Fax: 617-924-9998
http://www.braintumor.org