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Harvard Medical School
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General Medical Questions
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Q: I had a severe allergic reaction to hair dye at a salon and was put on a series of steroids including prednisone, Medrol and Olux foam. During that time I discovered a lump in my breast, and after a core biopsy it was found to be benign. Could the steroid use cause a breast lump?
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The Trusted Source
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Harold J. DeMonaco, M.S.

Harold J. DeMonaco, M.S., is senior analyst, Innovative Diagnostics and Therapeutics, and the chair of the Human Research Committee at the Massachusetts General Hospital. He is author of over 20 publications in the pharmacy and medical literature and routinely reviews manuscript submissions for eight medical journals.

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October 13, 2004
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A:

There is no relationship between the use of the corticosteroids (prednisone, Medrol and Olux) and the breast lump.

Most permanent hair dyes contain a chemical called paraphenylenediamine, or PPD. Although most people can tolerate PPD, some people can have severe allergic reactions. People allergic to PPD should not use any permanent hair dyes. About one in four people allergic to PPD are also allergic to ingredients in semi-permanent dyes. These dyes are called oxidation dyes, and someone who has had an allergic reaction should avoid both. Metallic and vegetable hair dyes do not contain PPD.

People who have had a reaction to hair dye should make certain that their physicians and dentists know about it. PPD is closely related to some of the anesthetics (numbing drugs) used by dentists and physicians.


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