July 9, 2002 SAN FRANCISCO (AP) -- With the jab of a needle, volunteers are being injected with a smallpox vaccine as part of government-sponsored experiments that come amid heightened fear of biological terrorism.
About 330 volunteers will be inoculated with diluted doses of the vaccine over the next two weeks at four sites across the nation. On Monday, the Oakland Medical Center began vaccinating 50 volunteers.
Researchers will test two vaccines. One, known as Dryvax, was made 20 years ago and consists of 15 million doses. The other is more than 70 million doses that Aventis Pasteur Inc. donated to the government, which now must determine whether the vaccines are still useable.
For decades, Aventis' doses sat nearly unnoticed in a walk-in freezer at a remote mountainside lab in Pennsylvania. The firm thought the contents of their freezer were so worthless they were planning to destroy the stockpile.
Then came Sept. 11 and the ensuing anthrax attacks.
Suddenly the nation's available supply of vaccine for smallpox, a disease that had been declared eradicated worldwide in 1980, was deemed crucial.
"In the past year, I think we've all become more aware of the possibility of a bioterrorist attack in the United States," said Steve Black, co-director of the Vaccine Research Center at Oakland Medical Center.
"I hope we never need to use this vaccine again, but it's important to make certain that if we do it will be available and it will work," Black said. "If we can show that this vaccine stock is still effective, it will go a long way toward making a dose of smallpox vaccine available for everyone in the U.S."
Volunteers have already begun receiving the vaccine at Vanderbilt University in Nashville, Tenn., and the University of Iowa. Baylor College of Medicine, in Houston, also is enrolling volunteers. Results are expected by mid-August.
The tests are part of a $12.6 million National Institutes of Health grant awarded last year to Vanderbilt, which is overseeing the experiment and will enroll about 90 volunteers of its own.
Federal officials at the Centers for Disease Control and Prevention now are considering vaccinating as many as 500,000 health care workers and emergency personnel who would be first to see any smallpox cases. Because the vaccine carries significant risks -- including death -- officials do not want to resume mass vaccinations.
Bioterrorism experts consider the possibility of a smallpox attack one of the most frightening, albeit unlikely, threats because one infected patient could infect many others.
Health workers will inject the vaccine, the area will be bandaged and the area will be checked. Subsequent blood tests will determine whether the test subjects develop the antibodies needed to fight off the disease.
Two studies released in March by The New England Journal of Medicine found that out of the 700 previously unvaccinated young adults who received some of the Dryvax vaccine, one-third had pain bad enough to miss school, work or other activities after being inoculated. While no one in the study fell seriously ill, some experienced fever, headache, nausea, muscle aches, lesions and swelling.
Copyright 2002 The Associated Press. All rights reserved.
