In peripheral vascular disease, not enough blood flows to the legs. The condition usually is caused by fatty deposits called plaques that build up along the walls of blood vessels. This buildup shrinks the size of the passageway and reduces the amount of blood that can flow through. This is a condition called atherosclerosis. The most common symptom is intermittent claudication, a cramping in the legs or buttocks when you exercise that goes away when you rest. The risk factors for getting peripheral vascular disease are similar to the risk factors for coronary heart disease, and include:

• Smoking cigarettes or using other forms of tobacco (such as snuff and chew)
• An abnormally high level of cholesterol (hypercholesterolemia)
• An abnormally low level of high-density lipoprotein (HDL, the good cholesterol)
• High blood pressure (hypertension)
• Diabetes
• Family history of cardiovascular disease
• Obesity
• Physical inactivity (too little regular exercise)
• Kidney disease
• Race (Blacks appear to have a higher risk of developing the disease)

The most common symptom of peripheral vascular disease is pain or cramping in the legs or buttocks that starts when you exercise and goes away when you rest. Often the pain is described as a deep ache, especially in the calf muscle. The pain may extend to the foot or up toward the thigh and buttock. Sometimes, there is just numbness in the leg or a sense that one leg gets tired when you walk. A foot or toes also may feel cold or numb.

If the arteries are severely narrowed, you could experience leg pain when you are not exercising. If blood flow stops completely (usually because a blood clot forms in the narrowed vessel), parts of the leg may become pale or turn blue, feel stone cold to the touch and eventually develop gangrene.

Your doctor will review your personal risk factors for atherosclerosis and your family history. Your doctor will ask if you or any family members have heart disease, high cholesterol, diabetes, kidney disease, high blood pressure or any other circulation disorder. During the physical examination, your doctor will feel the pulse in your upper leg (near the groin), on the inside of your ankle, the top of your foot and the back of your knee. Any weakness in a pulse may be a sign of narrowed arteries.

Usually the doctor can diagnose peripheral vascular disease based on your symptoms, risk factors, the examination of your legs and the strength of your pulses. Other tests include blood pressure measurements taken at various locations in the legs, Doppler studies of blood flow, special ultrasound testing and exercise testing on a treadmill. If your doctor suspects that you need a procedure to help open a blocked blood vessel, you may need a magnetic resonance imaging (MRI) scan of your arteries or an angiogram, which is an X-ray test that uses dye in the narrowed arteries to reveal the pattern of blood flow and spot blockages.

Once you have peripheral vascular disease, your arteries usually will remain narrowed. However, even though your arteries are narrowed, your symptoms can decrease and even go away with treatment.

You can help to prevent peripheral vascular disease by modifying your risk factors:

• Don't smoke. This a major risk factor that you can control.
• Maintain a healthy weight. Obesity, especially a concentration of body fat around the waist, has been linked to unhealthy blood levels of cholesterol and other fats, which can build up inside your arteries.
• Eat a healthy diet. Your diet should be loaded with vegetables and fruits, and it should be low in saturated fats.
• Exercise regularly. Ideally, you should exercise 45 minutes or more every day.
• Lower your blood pressure. Medications may be necessary if maintaining a healthy lifestyle is not enough.

Treatment for peripheral vascular disease includes:

• Modifying risk factors — Quitting smoking can reduce the symptoms of intermittent claudication and decrease the likelihood that the disease will get worse. It is also important to lower your cholesterol levels if they are high, keep blood pressure in the normal range, and keep your diabetes well-controlled. Talk to your doctor about the best way to do this.



• Exercise programs — Studies have shown that people who exercise can nearly double the distance they can walk before they start feeling leg pain. Try to exercise at least 30 minutes every day. You may need frequent breaks if your legs hurt. Even if you have to stop every few minutes, don't give up. Any activity is very beneficial. Most people choose walking, and find that walking on a track or a treadmill is easier than walking on pavement. You could also try bike riding (stationary or standard) and swimming.



• Medications — Even if you exercise and modify your risk factors, medications can help you to better relieve symptoms and may help to slow the progression of the disease. Your doctor probably will advise you to take aspirin every day, or to take another blood-thinning medication, such as clopidogrel (Plavix). Medications, such as cilostazol (Pletal) and pentoxifylline (Trental), also can help to decrease the symptoms of intermittent claudication.



• Revascularization procedures —The goal of revascularization is to improve circulation, either by opening narrowed arteries or by bypassing the narrowed section of the artery. These procedures include surgical and nonsurgical techniques and are used in people who have severe or progressive symptoms, or whose leg pain occurs at rest. The most common nonsurgical procedure is percutaneous transluminal angioplasty, also called balloon angioplasty. In this procedure, a catheter is inserted into the narrowed artery and a small balloon at the tip is inflated to open the narrowed vessel. Often, a metallic implant called a stent is used as a scaffold to support the wall of the artery after it is opened with the balloon. In some people, the narrowed vessel must be bypassed surgically using either a section of vein taken from the leg or a synthetic graft.

Call your doctor if you consistently suffer from cramps, aching, numbness or disproportionate fatigue in your leg muscles or buttocks when you exercise. Call immediately if you have these symptoms at rest or when any part of your leg or foot suddenly turns numb, cold, pale or a bluish color.

In most people with peripheral vascular disease, leg symptoms remain stable. About 10% to 15% of patients improve, and about 15% to 20% get worse. The outlook is better for people who are able to remain tobacco-free, stay on a healthy diet, keep their blood cholesterol under control and exercise regularly.

National Heart, Lung and Blood Institute (NHLBI)
P.O. Box 30105
Bethesda, MD 20824-0105
Phone: (301) 592-8573
E-Mail: NHLBIinfo@rover.nhlbi.nih.gov
http://www.nhlbi.nih.gov/